United States securities and exchange commission logo May 24, 2022 Michael Egholm Chief Executive Officer Standard Biotools Inc. 2 Tower Place, Ste 2000 South San Francisco, California 94080 Re: Standard Biotools Inc. Registration Statement on Form S-3 Filed May 17, 2022 File No. 333-265010 Dear Dr. Egholm: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Tyler Howes at 202-551-3370 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Zachary Myers, Esq.