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                           November 27, 2023

       Michael Egholm, Ph.D.
       President and Chief Executive Officer
       STANDARD BIOTOOLS INC.
       2 Tower Place, Suite 2000
       South San Francisco, CA 94080

                                                        Re: STANDARD BIOTOOLS
INC.
                                                            Registration
Statement on Form S-4
                                                            Filed November 13,
2023
                                                            File No. 333-275533

       Dear Michael Egholm:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Jessica
Ansart at 202-551-4511 with any questions.




                           Sincerely,


                           Division of Corporation Finance

                           Office of Industrial Applications and

                           Services
       cc:                                              Matthew Gardella