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                          February 1, 2024

       Michael Egholm
       President and Chief Executive Ofiicer
       Standard BioTools Inc.
       2 Tower Place
       Suite 2000
       South San Francisco, CA 94080

                                                        Re: Standard BioTools
Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed January 19,
2024
                                                            File No. 333-276626

       Dear Michael Egholm:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Robert
Augustin at 202-551-8483 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Industrial Applications and

                          Services
       cc:                                              John Rudy